Synthesis of Novel 2,6,9-Trisubstituted Purine Derivatives Coupled with L-Methionine at C2 Position and their Biological Evaluation as Potential Antimicrobial Agent

A series of novel 2, 6-diamino-9-methyl purine derivatives coupled with N-Phthaloyl and carboxamide derivatives of L-methionine at the C2 position were synthesized by coupling of 2, 6-diamino-9-methyl purine with N-protected Methionine using phosphorous oxychloride in pyridine. The synthesized compounds were characterized using different physicochemical analyses and IR, 1H, 13C–NMR, MS. The compounds were screened for their in vitro antimicrobial activity and demonstrated significant activity against the tested organisms. These compounds may prove useful as CDK inhibitors.