Pharmacological Effects of Novel Peptide Drugs on Allergic Rhinitis at the Small Ribonucleic Acids Level

An, Li-Feng and Li, Zhan-Dong and Li, Lin and Li, Hao and Yu, Jian (2020) Pharmacological Effects of Novel Peptide Drugs on Allergic Rhinitis at the Small Ribonucleic Acids Level. Frontiers in Genetics, 11. ISSN 1664-8021

[thumbnail of pubmed-zip/versions/1/package-entries/fgene-11-560812/fgene-11-560812.pdf] Text
pubmed-zip/versions/1/package-entries/fgene-11-560812/fgene-11-560812.pdf - Published Version

Download (7MB)

Abstract

Using an allergic rhinitis (AR) model, we evaluated the pharmacological effects of novel peptide drugs (P-ONE and P-TWO) at the small RNA (sRNA) level. Using high-throughput sequencing, we assessed the sRNA expression profile of the negative control, AR antagonist (positive control), P-ONE, and P-TWO groups. By functional clustering and Gene Ontology and KEGG pathway analyses, we found that sRNA target genes have a specific enrichment pattern and may contribute to the effects of the novel peptides. Small RNA sequencing confirmed the biological foundations of novel and traditional AR treatments and suggested unique pharmacological effects. Our findings will facilitate evaluation of the pathogenesis of AR and of the pharmacological mechanisms of novel peptide drugs.

Item Type: Article
Subjects: Afro Asian Archive > Medical Science
Depositing User: Unnamed user with email support@afroasianarchive.com
Date Deposited: 10 Feb 2023 11:55
Last Modified: 24 Jun 2024 05:19
URI: http://info.stmdigitallibrary.com/id/eprint/141

Actions (login required)

View Item
View Item